Polyclonal and monoclonal antibody therapy for experimental Pseudomonas aeruginosa pneumonia
نویسندگان
چکیده
منابع مشابه
Granulocyte transfusion therapy of experimental Pseudomonas pneumonia.
Pseudomonas pneumonia was produced in dogs with radiation-induced leukopenia. Treatment of this infection with either gentamicin alone or gentamicin plus daily granulocyte transfusion was compared in a randomized controlled trail. The dogs receiving granulocytes plus gentamicin survived significantly longer than those treated with gentamicin alone (P < 0.05). The Pseudomonas immunotype which wa...
متن کاملComparison of polyclonal rabbit antisera with monoclonal antibodies for serological typing of Pseudomonas aeruginosa.
A panel of 219 distinct strains of Pseudomonas aeruginosa were serotyped with a set of monoclonal antibodies prepared against the serotype strains of the Homma scheme (J. Y. Homma, Jpn. J. Exp. Med. 46:329-336, 1976). A total of 87.6% were typable, and there was very good agreement with the corresponding polyclonal serotype. A high proportion of strains that were polyagglutinating or nontypable...
متن کاملExperimental Pseudomonas aeruginosa pneumonia: evaluation of the associated inflammatory response.
An abnormal inflammatory response (IR) in pneumonia is associated with poor outcomes and high mortality. Animal models could help to better understand the relationship between the pulmonary infection and the associated IR. The aims of the present study were to validate an experimental model of pneumonia induced by the inoculation of Pseudomonas aeruginosa in ventilated piglets and to study the ...
متن کاملRole of apoptosis in Pseudomonas aeruginosa pneumonia.
Apoptosis plays a central role in the complex balance between invading pathogen and host defense. Depending on the pathogen, apoptosis of host cells may be beneficial or detrimental to survival. Studies using a clinically relevant intra-abdominal model of sepsis (peritonitis) have indicated that two types of cells, lymphocytes and gastrointestinal epithelial cells, undergo accelerated apoptosis...
متن کاملPseudomonas aeruginosa induces localized immunosuppression during pneumonia.
Hospital-acquired bacterial pneumonia is a common and serious complication of modern medical care. Many aspects of such infections remain unclear, including the mechanisms by which invading pathogens resist clearance by the innate immune response and the tendency of the infections to be polymicrobial. Here, we used a mouse model of infection to show that Pseudomonas aeruginosa, a leading cause ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1986
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.54.1.239-244.1986